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原著論文

The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC

Fuseya, Y., Fujita, H., Kim, M., Ohtake, F., Nishide, A., Sasaki, K., Saeki, Y., Tanaka, K., Takahashi, R. and Iwai, K.

Nature Cell Biology 22(6): 663-673, 2020. DOI

LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic stress.

Jo, T., Nishikori, M., Kogure, Y., Arima, H., Sasaki, K., Sasaki, Y., Nakagawa, T., Iwai, F., Momose, S., Shiraishi, A., Kiyonari, H., Kagaya, N., Onuki, T., Shin-ya, K., Yoshida, M., Kataoka, K., Ogawa, S., Iwai, K. and Takaori-Kondo, A.

Blood 136(6): 684-697, 2020. DOI

Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.

Sasaki, K., Himeno, A., Nakagawa, T., Sasaki, Y., Kiyonari, H. and Iwai, K.

Nature Commun. 10(1):3878, 2019. DOI

Hydrophobic CDR3 residues promote the development of self-reactive T cells

Stadinski BD, Shekhar K, Gomez-Tourino I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES

Nat Immunol. 17, 946-55, 2016. DOI

Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms

Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M

Front Cell Neurosci. 5, 295, 2015.

Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells

Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S

Nat Commun. 23, 7484, 2015.

Measurement of Proteasome Activity in Peripheral Blood Mononuclear Cells as an Indicator of Susceptivility of Bortezomib-induced Severe Neurological Adverse Events in Patients with Multiple Myeloma

Cho Y, Hori M, Okoshi Y, Fujisawa F, Shinagawa A, Kudo D, Komeno T, Yoshida C, Katsura Y, Ota I, Shimizu S, Kamoshita M, Sasaki K, Tanaka K, Mukai HY, Kojima H

Acta Haematol. 134, 25-31, 2015.

Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells

Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES

J Immunol. 192, 3029-42, 2014. DOI

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, Kisselev AF, Overkleeft HS

Chem Biol. 27, 795-801, 2010

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis

Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S

Mol Cell Biol. 30, 3864-74, 2010.

Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells

Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y

Immunity. 29, 29-40, 2010.

Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones

Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S

Cell 29, 914-25, 2009. DOI

Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development

Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S

Mol Cell Biol. 27, 6629-38, 2007.

Regulation of CD8+ T cell development by thymus-specific proteasomes

Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K

Science 1, 1349-53, 2007. DOI

総説論文

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.

Sasaki, K. and Iwai, K

Immunol. Rev. 266:175-189, 2015.