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We are working on further exploring our original discoveries in the fields of signal transduction and cell death control by linear ubiquitin chains and cellular iron metabolism. We also trying to make brand-new discoveries – i.e., independently of any previous research.

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Access/Contact
Kyoto University
Faculty of Medicine campus Bldg. C 5F
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501,
JAPAN
TEL： +81-75-753-4673

Publications

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress.

Douglas T., Nie P., Zhang J., Abdallah KS., Wu Z., McReynolds M., Iwai K., Peng J., Gilbert WV., Young LH., Crews CM.

Nat Cell Biol 28(5):930-945 (2026) DOI

Asymmetry in ubiquitin binding by A20 reveals early recognition features of the ubiquitin code

Walinda E., McCarthy-Page JR., Iwai K., Morimoto D.

FEBS Lett 600(9), 1340-1354 (2026) DOI

Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function

Toda Y., Fujita H., Mino K., Koyama T., Matsuoka S., Kaizuka T., Agawa M., Matsumoto S., Idei A., Nishikori M., Okuno Y., Osada H., Yoshida M., Takaori-Kondo A. & Iwai K.

Cell Death & Disease 15, Article number: 813 (2024) DOI

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