We are working on further exploring our original discoveries in the fields of signal transduction and cell death control by linear ubiquitin chains and cellular iron metabolism. We also trying to make brand-new discoveries – i.e., independently of any previous research.


Kyoto University
Faculty of Medicine campus Bldg. C 5F
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501,
TEL: +81-75-753-4673


Oxygen modulates iron homeostasis by switching iron-sensing of NCOA4

Kuno S, Iwai K.

J Biol Chem. J Biol Chem. 2023 Apr 12:104701. doi: 10.1016/j.jbc.2023.104701. Online ahead of print. DOI

Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion

Sasaki K, Hayamizu Y, Murakami R, Toi M, Iwai K.

FEBS Lett. FEBS Lett. 2023 May;597(9):1193-1212.doi: 10.1002/1873-3468.14623. Epub 2023 Apr 27. DOI

Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5

Hiragi K, Nishide A, Takagi K, Iwai K, Kim M, Mizushima T.

J Biochem. 2023 Mar 31;173(4):317-326. doi: 10.1093/jb/mvac109. DOI

View all