We are working on further exploring our original discoveries in the fields of signal transduction and cell death control by linear ubiquitin chains and cellular iron metabolism. We also trying to make brand-new discoveries – i.e., independently of any previous research.


Kyoto University
Faculty of Medicine campus Bldg. C 5F
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501,
TEL: +81-75-753-4673


Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5

Hiragi K, Nishide A, Takagi K, Iwai K, Kim M, Mizushima T.

J Biochem. 2023 Jan 4:mvac109. doi: 10.1093/jb/mvac109. Online ahead of print. PMID: 36610722 DOI

Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation

Sakamoto Y, Sasaki K, Omatsu M, Hamada K, Nakanishi Y, Itatani Y, Kawada K, Obama K, Seno H, Iwai K.

The Journal of Pathology. 2023 Mar;259(3):304-317. doi: 10.1002/path.6042. Epub 2022 Dec 20. PMID: 36454102 DOI

Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia

Jimbo K, Hattori A, Koide S, Ito T, Sasaki K, Iwai K, Nannya Y, Iwama A, Tojo A, Konuma T.

Leukemia. 2023 Jan;37(1):122-133. doi: 10.1038/s41375-022-01750-7. Epub 2022 Nov 9. DOI

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