Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function
Toda Y., Fujita H., Mino K., Koyama T., Matsuoka S., Kaizuka T., Agawa M., Matsumoto S., Idei A., Nishikori M., Okuno Y., Osada H., Yoshida M., Takaori-Kondo A. & Iwai K.
Cell Death & Disease
15, Article number: 813 (2024)
DOI
PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis
Fujita H., Tanaka Y., Ogata S., Suzuki N., Kuno S., Barayeu U., Akaike T., Ogra Y. and Iwai K.
Nature structural & molecular biology
12 June (2024)
DOI
A de novo dominant-negative OTULIN variant is associated with OTULIN Related Autoinflammatory Syndrome.
Takeda Y., Ueki M., Matsuhiro J., Walinda E., Tanaka T., Yamada M., Fujita H., Takezaki S., Kobayashi I., Tamaki S., Nagata S., Miyake N., Matsumoto N., Osawa M., Yasumi T., Heike T., Ohtake F., Saito M. K., Toguchida J., Takita J., Ariga T., and Iwai K.
J. Exp. Med.
221(6):e20231941 (2024)
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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.
Oda H., Manthiramm K., Chavan P.P., Rieser E., Veli Ö., Kaya Ö., Rauch C., Nakabo S., Kuehn H.S., Swart M., Wang Y., Çelik N.I., Molitor A., Ziaee V., Movahedi N., Shahrooei M., Parvaneh N., Alipour-Olyei N., Carapito R., Xu Q., Preite S., Beck D.B., Chae J.J., Nehrebecky M., Ombrello A.K., Hoffmann P., Romeo T., Deuitch N.T., Matthíasardóttir B., Mullikin J., Komarow H., Stoddard J., Niemela J., Dobbs K., Sweeney C.L., Anderton H., Lawlor K.E., Yoshitomi H., Yang D., Boehm M., Davis J., Mudd P., Randazzo D., Tsai W.L., Gadina M., Kaplan M.J., Toguchida J., Mayer C.T., Rosenzweig S.D., Notarangelo L.D., Iwai K., Silke J., Schwartzberg P.L., Boisson B., Casanova J.L., Bahram S., Rao A.P., Peltzer N., Walczak H., Lalaoui N., Aksentijevich I., and Kastner D.L.
Nat. Immunol.
2024, Apr 12
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HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes
Akagi K, Baba S, Fujita H, Fuseya Y, Yoshinaga D, Kubota H, Kume E, Fukumura F, Matsuda K, Tanaka T, Hirata T, Saito M, Iwai K, Takita J
scientific reports
2024 Apr 17;14(1):8871.
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Myofiber-type-dependent 'boulder' or 'multitudinous pebble' formations across distinct amylopectinoses
Mitra S, Chen B, Shelton JM, Nitschke S, Wu J, Covington L, Dear M, Lynn T, Verma M, Nitschke F, Fuseya Y, Iwai K, Evers BM, Minassian BA.
Acta Neuropathol.
2024 Feb 27;147(1):46.
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Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling
Fuseya Y, Kadoba K, Liu X, Suetsugu H, Iwasaki T, Ohmura K, Sumida T, Kochi Y, Morinobu A, Terao C, Iwai K.
JCI Insight
2024 Feb 8;9(3):e171108
DOI
