• Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.

    Shabek, N., Iwai, K., and Ciechanover, A.
    Biochem. Biophys. Res. Commun. 363:425-431, 2007.

  • Heme induces ubiquitination and degradation of the transcription factor Bach1.

    Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K. and Igarashi, K.
    Mol. Cell. Biol. 27:6962-6971, 2007.

  • Cerebral vascular accumulation of Dutch-type Ab42, but not wild-type Ab42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.

    Nishitsuji, K., Tomiyama, T., Ishibashi .K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A., Iwai, K. and Mori, H.
    J. Neurosci. Res. 85:2917-2923, 2007.

  • Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.

    Ueta, R., Fujiwara, N., Iwai, K. (corresponding author) and Yamaguchi-Iwai, Y.
    Mol. Biol. Cell 18:2980-2990, 2007.

  • A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.

    Yoshida, Y., Murakami, A., Iwai, K. and Tanaka, K.
    J. Biol. Chem. 282:7137-7144, 2007.

  • Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity.

    Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K. and Kato, K.
    Nature Struct. Mol. Biol. 14:167-168, 2007.