HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I.

Am. J. Respir, Crit. Care Med. 190(6):688-98, 2014. doi: 10.1164/rccm.201403-0463OC.

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

Rodgers, M.A., Bowman, J.W., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T.J., Iwai, K., Ting, J., Jung, J. U.
J. Exp. Med. 211: 1333-1347, 2014. doi:.10.1084/jem.20132486.

IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

Tamiya, H., Terao, M., Takiuchi, T., Nakahara, M., Sasaki, Y., Katayama, I., Yoshikawa, H., and Iwai K.
J. Immunol. 192:3793-3804, 2014.

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

Yang, Y., Schmitz, R., Mitala, J. J. Jr., Whiting, A., Xiao, W., Ceribelli, M., Wright, G. W., Zhao, H., Yang, Y., Xu, W., Rosenwald, A., Ott, G., Gascoyne, R. D., Connors, J. M., Rimsza, L. M., Campo, E., Jaffe, E. S., Delabie, J., Smeland, E. B., Braziel, R. M., Tubbs, R. R., Cook, J. R., Weisenburger, D. D., Chan, W. C., Wiestner, A., Kruhlak, M. J., Iwai, K., Bernal, F., and Staudt, L. M.
Cancer Discov. 4:480-493, 2014.

Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).

Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.
Mol. Cell. Biol.  34:1322-1335, 2014.

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.
Genes Cells. 19:254-272, 2014.