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  • The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

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  • LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.

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  • A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by fenton reaction.

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  • Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells.

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  • SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

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  • SHARPIN is a component of the NF-κB activating linear ubiquitin chain assembly complex.

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  • Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction.

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  • Unusual heme binding in the bacterial iron response regulator protein (Irr): Spectral characterization of heme binding to heme regulatory motif.

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  • RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-κB pathway.

    Shimada, K., Saeki, M., Egusa, H., Fukuyasu, S., Yura, Y., Iwai, K., and Kamisaki, Y.
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