• HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.

    MacDuff, D.A., Baldridge, M.T., Qaqish, A.M., Nice, T.J., Darbandi, A.D., Hartley, V.L., Peterson, S.T., Miner, J.J., Iwai, K. and Virgin, H.W.

    J. Virol. 92(23). pii: e01368-18. doi: 10.1128/JVI.01368-18, 2018.

  • Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization.

    Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K.  

    Cell Reports 23(4):1192-1204, 2018. DOI: https://doi.org/10.1016/j.celrep.2018.03.112

  • Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development.

    Sasaki, Y. and Iwai, K.

    J. Immunol. 200(10):3438-3449, 2018. https://doi.org/10.4049/jimmunol.1701526


  • Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

    Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T.H., Iwai, K., Dawson, V.L., Dawson, T.M., and Takahashi, R.  

    Stem Cell Reports 10(2):356-365, 2018   doi: 10.1016/j.stemcr.2017.12.001.

  • Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins.

    Ogura, M., Endo, R., Ishikawa, H., Takeda, Y., Uchida, T., Iwai, K., Kobayashi, K., and Ishimori, K  

    J. Inorg. Biochem. 182:238-248. doi: 10.1016/j.jinorgbio.2018.01.007.

  • SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

    Tamiya, H., Kim, H., Klymenko, O., Kim, H., Feng, Y., Zhang, T., Han, J.Y., Murao, A., Snipas, S.J., Jilaveanu, L., Brown, K., Kluger, H., Zhang, H., Iwai, K., and Ronai, Z.A.  

    J. Clin. Invest. 128(1):517-530, 2018. doi: 10.1172/JCI95410.