Members

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特定講師

藤田宏明

Hiroaki Fujita

fujisan [at] mcp.med.kyoto-u.ac.jp

Message

これまでLUBACの仕事をしていましたが、心機一転、鉄依存性の細胞死の研究をはじめました。面白い現象を報告できるように日夜奮闘中です。

Projects

直鎖状ユビキチン鎖の機能解析

LUBAC機能制御薬の創成

細胞内鉄動態、フェロトーシスの解析

Publications

原著論文

The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC

Fuseya, Y., Fujita, H., Kim, M., Ohtake, F., Nishide, A., Sasaki, K., Saeki, Y., Tanaka, K., Takahashi, R. and Iwai, K.

Nature Cell Biology 22(6): 663-673, 2020. DOI

Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization.

Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K.

Cell Reports 23(4):1192-1204, 2018. DOI

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.

Genes Cells. 19:254-272, 2014.

Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).

Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.

Mol. Cell. Biol. 34:1322-1335, 2014.

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.

Morita, D., Yamamoto, Y., Mizutani, T., Ishikawa, T., Suzuki, J., Igarashi, T., Mori, N., Shiina, T., Inoko, H., Fujita, H., Iwai, K., Tanaka, Y., Mikami, B., and Sugita, M.

Nat. Commun. Jan 13;7:10356, 2016. DOI

Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection.

Shimizu, S., Fujita, H., Sasaki, Y., Tsuruyama, T., Fukuda, K., and Iwai, K.

Mol. Cell. Biol. 36:1569-1583, 2016. DOI

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

Rodgers, M.A., Bowman, J.W., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T.J., Iwai, K., Ting, J., Jung, J. U.

J. Exp. Med 211: 1333-1347, 2014. DOI

Non-canonical UBA–UBL interaction mediates formation of linear ubiquitin chain assembly complex.

Yagi, H., Ishimoto, K., Takeshi Hiromoto, T., Fujita, H., Mizushima, T., Uekusa, Y., Yagi-Utsumi, M., Kurimoto, E., Noda, M., Uchiyama, S., Tokunaga, F., Iwai, K. (Correspondence author) and Kato, K.

EMBO Rep. 13:462-468, 2012.

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

Sato, Y., Fujita, H., Yoshikawa, A.,Yamashita, M., Yamagata, A., Kaiser, S. E., Iwai, K., and Fukai, S.

Proc. Natl. Acad. Sci. USA 108:20520-20525, 2011. DOI

総説論文

Linear ubiquitin chains: NF-κB signalling, cell death, and beyond.

Iwai, K., Fujita, H., and Sasaki, Y

Nature Rev. Mol. Cell Biol. 15:503-508, 2014. doi: 10.1038/nrm3836.

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