Publications


HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes

Akagi K, Baba S, Fujita H, Fuseya Y, Yoshinaga D, Kubota H, Kume E, Fukumura F, Matsuda K, Tanaka T, Hirata T, Saito M, Iwai K, Takita J

scientific reports 2024 Apr 17;14(1):8871. DOI

Myofiber-type-dependent 'boulder' or 'multitudinous pebble' formations across distinct amylopectinoses

Mitra S, Chen B, Shelton JM, Nitschke S, Wu J, Covington L, Dear M, Lynn T, Verma M, Nitschke F, Fuseya Y, Iwai K, Evers BM, Minassian BA.

Acta Neuropathol. 2024 Feb 27;147(1):46. DOI

Attenuation of HOIL-1L ligase activity promotes systemic autoimmune disorders by augmenting linear ubiquitin signaling

Fuseya Y, Kadoba K, Liu X, Suetsugu H, Iwasaki T, Ohmura K, Sumida T, Kochi Y, Morinobu A, Terao C, Iwai K.

JCI Insight 2024 Feb 8;9(3):e171108 DOI

HOIL1 Regulates Group 3 Innate Lymphoid Cells in the Colon and Protects against Systemic Dissemination, Colonic Ulceration, and Lethality from Citrobacter rodentium Infection

Hartley VL, Qaqish AM, Wood MJ, Studnicka BT, Iwai K, Liu TC, MacDuff DA.

J Immunol. 2023 Dec 15;211(12):1823-1834. DOI

Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity

Walinda E, Sugase K, Ishii N, Shirakawa M, Iwai K, Morimoto D.

J Biol Chem. 2023 Sep;299(9):105165.doi: 10.1016/j.jbc.2023.105165. Epub 2023 Aug 16. DOI

Oxygen modulates iron homeostasis by switching iron-sensing of NCOA4

Kuno S, Iwai K.

J Biol Chem. J Biol Chem. 2023 Apr 12:104701. doi: 10.1016/j.jbc.2023.104701. Online ahead of print. DOI

Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion

Sasaki K, Hayamizu Y, Murakami R, Toi M, Iwai K.

FEBS Lett. FEBS Lett. 2023 May;597(9):1193-1212.doi: 10.1002/1873-3468.14623. Epub 2023 Apr 27. DOI

Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5

Hiragi K, Nishide A, Takagi K, Iwai K, Kim M, Mizushima T.

J Biochem. 2023 Mar 31;173(4):317-326. doi: 10.1093/jb/mvac109. DOI

Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation

Sakamoto Y, Sasaki K, Omatsu M, Hamada K, Nakanishi Y, Itatani Y, Kawada K, Obama K, Seno H, Iwai K.

The Journal of Pathology. 2023 Mar;259(3):304-317. doi: 10.1002/path.6042. Epub 2022 Dec 20. PMID: 36454102 DOI

Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia

Jimbo K, Hattori A, Koide S, Ito T, Sasaki K, Iwai K, Nannya Y, Iwama A, Tojo A, Konuma T.

Leukemia. 2023 Jan;37(1):122-133. doi: 10.1038/s41375-022-01750-7. Epub 2022 Nov 9. DOI

HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine

Wood MJ, Marshall JN, Hartley VL, Liu TC, Iwai K, Stappenbeck TS, MacDuff DA.

Mucosal Immunol. 2022 Apr;15(4):642-655. doi: 10.1038/s41385-022-00520-z. Epub 2022 May 9. DOI

Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis

Kuno, S., Fujita, H., Tanaka, Y., Ogra, Y. and Iwai, K.

EMBO rep. 2022 May 4;23(5):e54278. DOI

ABIN1 is a signal-induced autophagy receptor that attenuates NF-kappaB activation by recognizing linear ubiquitin chains

Shinkawa, Y., Imami, K., Fuseya, Y., Sasaki, K., Ohmura, K., Ishihama, Y., Morinobu, A., Iwai, K.

FEBS Lett. 2022 May;596(9):1147-1164. DOI

Glycogen synthase downregulation rescues the amylopectinosis of murine RBCK1 deficiency

Nitschke, S., Sullivan, M.A., Mitra, S., Marchioni, C.R., Lee, J.P.Y., Smith, B.H., Ahonen, S., Wu, J., Chown, E.E., Wang, P., Petković, S., Zhao, X., DiGiovanni, L.F., Perri, A.M., Israelian, L., Grossman, T.R., Kordasiewicz, H., Vilaplana, F., Iwai, K., Nitschke, F., Minassian, B.A.

Brain 2022 Jul 29;145(7):2361-2377. DOI

Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures.

Walinda, E., Morimoto, D., Sorada, T., Iwai, K. and Sugase, K.

Protein Expr. Purif. 187:105953, 2021. DOI

Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.

Yoshida, Y., Asahina, M., Murakami, A., Kawawaki, J., Yoshida, M., Fujinawa, R., Iwai, K., Tozawa, R., Matsuda, N., Tanaka, K. and Suzuki, T.

Proc. Natl. Acad. Sci. USA 118(27): e2102902118, 2021. DOI

Structural dynamic heterogeneity of polyubiquitin subunits affects phosphorylation susceptibility.

Morimoto, D., Walinda, E., Takashima, S., Nishizawa, M., Iwai, K., Shirakawa, M. and Sugase, K.

Biochemistry 60(8):573-583, 2021. DOI

LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic stress.

Jo, T., Nishikori, M., Kogure, Y., Arima, H., Sasaki, K., Sasaki, Y., Nakagawa, T., Iwai, F., Momose, S., Shiraishi, A., Kiyonari, H., Kagaya, N., Onuki, T., Shin-ya, K., Yoshida, M., Kataoka, K., Ogawa, S., Iwai, K. and Takaori-Kondo, A.

Blood 136(6): 684-697, 2020. DOI

The HOIL-1L ligase modulates immune signaling and cell death via mono-ubiquitination of LUBAC

Fuseya, Y., Fujita, H., Kim, M., Ohtake, F., Nishide, A., Sasaki, K., Saeki, Y., Tanaka, K., Takahashi, R. and Iwai, K.

Nature Cell Biology 22(6): 663-673, 2020. DOI

Linear ubiquitin assembly complex regulates lung epithelial-driven responses during influenza infection.

Brazee, P.L., Morales-Nebreda, L., Magnani, N.D., Garcia, J.G., Misharin, A.V., Ridge, K.M., Budinger, G.R.S., Iwai, K., Dada, L.A., and Sznajder, J.I.

J. Clin. Invest. 130(3):1301-1314, 2020. DOI

Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.

Sasaki, K., Himeno, A., Nakagawa, T., Sasaki, Y., Kiyonari, H. and Iwai, K.

Nature Commun. 10(1):3878, 2019. DOI

Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance.

Nishitani, Y., Okutani, H., Takeda, Y., Uchida, T., Iwai, K. and Ishimori K.

J. Inorg. Biochem. 198:110726, 2019. DOI

NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.

Ishii, N., Walinda, E., Iwakawa, N., Morimoto, D., Iwai, K., Sugase, K. and Shirakawa, M.

Biomol. NMR Assign 13(1):149-153, 2019. DOI

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.

Wu, M., Chang, Y., Hu, H., Mu, R., Zhang, Y., Qin, X., Duan, X., Li, W., Tu, H., Zhang, W., Wang, G., Han, Q., Li, A., Zhou, T., Iwai, K., Zhang, X. and Li, H.

Nature Commun. 10(1):273, 2019. DOI

HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.

MacDuff, D.A., Baldridge, M.T., Qaqish, A.M., Nice, T.J., Darbandi, A.D., Hartley, V.L., Peterson, S.T., Miner, J.J., Iwai, K. and Virgin, H.W

J. Virol. 92(23). pii: e01368-18. doi: 10.1128/JVI.01368-18, 2018. DOI

Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization.

Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K.

Cell Reports 23(4):1192-1204, 2018. DOI

Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development.

Sasaki, Y. and Iwai, K.

J. Immunol. 200(10):3438-3449, 2018. DOI

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T.H., Iwai, K., Dawson, V.L., Dawson, T.M., and Takahashi, R.

Stem Cell Reports 10(2):356-365, 2018 DOI

Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins.

Ogura, M., Endo, R., Ishikawa, H., Takeda, Y., Uchida, T., Iwai, K., Kobayashi, K., and Ishimori, K

J. Inorg. Biochem 182:238-248. DOI

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

Tamiya, H., Kim, H., Klymenko, O., Kim, H., Feng, Y., Zhang, T., Han, J.Y., Murao, A., Snipas, S.J., Jilaveanu, L., Brown, K., Kluger, H., Zhang, H., Iwai, K., and Ronai, Z.A.

J. Clin. Invest 128(1):517-530, 2018. DOI

HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.

Magnani, N.D., Dada, D.A., Queisser, M,A., Brazee, P., Welch, L,C., Anekalla, K., Zhou, G., Misharin, A., Budinger, G.R.S., Iwai, K., Ciechanover, A.J., and Sznajder J.I

Proc. Natl. Acad. Sci. USA. 114(47):E10178-E10186, 2017. doi: 10.1073/pnas.1713563114. DOI

Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy.

Yoshida, Y., Yasuda, S., Fujita, T., Hamasak,i M., Murakami, A., Kawawaki, J., Iwai, K., Saeki, Y., Yoshimori, T., Matsuda, N., and Tanaka, K.

Proc. Natl. Acad. Sci. USA 114(32):8574-8579. 2017 Jul 25. pii: 201702615. DOI

HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Met1-linked hybrid polyubiquitin chains.

Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, J.I.

PLoS Pathog. 13(1):e1006162, 2017. DOI

Survival of mature T cells depends on signaling through HOIP.

Okamura, K., Kitamura, A., Sasaki, Y., Chung, D.H., Kagami, S., Iwai, K., and Yasutomo, K.

Sci. Rep. 6:34990, 2016. DOI

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles.

Yamano, Y., Sugimoto, M., Hirayama, A., Kume, S., Yamato, M., Jin, G., Tajima, S., Goda, N., Iwai, K., Fukuda, S., Yamaguti, K., Kuratsune, H., Soga, T., Watanabe, Y., and Kataoka, Y.

Sci. Rep. 6:34990, 2016. DOI

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa, S., Oikawa, D., Ishii, R., Ayaki, T., Takahashi, H., Takeda, H., Ishitani, R., Kamei, K., Takeyoshi, I., Kawakami, H.,Iwai, K., Hatada, I., Sawasaki, T., Ito, H., Nureki, O., and Tokunaga, F.

Nat Commun Aug 24;7:12547. DOI

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa, S., Oikawa, D., Ishii, R., Ayaki, T., Takahashi, H., Takeda, H., Ishitani, R., Kamei, K., Takeyoshi, I., Kawakami, H.,Iwai, K., Hatada, I., Sawasaki, T., Ito, H., Nureki, O., and Tokunaga, F.

Nat Commun. Aug 24;7:12547, 2016. DOI

Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein.

Kobayashi, K., Nakagaki, M., Ishikawa, H., Iwai, K., O'Brian, M.R., and Ishimori, K.

Biochemistry 55(29):4047-4054, 2016. DOI

Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection.

Shimizu, S., Fujita, H., Sasaki, Y., Tsuruyama, T., Fukuda, K., and Iwai, K.

Mol. Cell. Biol. 36:1569-1583, 2016. DOI

Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex.

Morita, D., Yamamoto, Y., Mizutani, T., Ishikawa, T., Suzuki, J., Igarashi, T., Mori, N., Shiina, T., Inoko, H., Fujita, H., Iwai, K., Tanaka, Y., Mikami, B., and Sugita, M.

Nat. Commun. Jan 13;7:10356, 2016. DOI

Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator.

Kitatsuji, C., Izumi, K., Nambu, S., Kurogochi, M., Uchida, T., Nishimura, S., Iwai, K., O'Brian, M. R., Ikeda-Saito, M., and Ishimori, K.

Sci. Rep. Jan 5;6:18703, 2016. DOI

Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.

Bowman, J., Rodgers, M.A., Shi, M., Amatya, R., Hostager, B., Iwai, K., Gao, S.J., and Jung, J.U.

MBio. 6(6). pii: e01777-15, 2015.

The Structural differences between a glycoprotein specific F-Box protein Fbs1 and its homologous protein FBG3.

Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T.

PLoS One 10(10):e0140366, 2015.

CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis.

Zhao, Y., Ma, C. A., Wu, L., Iwai, K., Ashwell, J. D., Oltz, E. M., Ballard, D. W., and Jain, A.

J. Biol. Chem. 290(36):22076-22084, 2015.

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

Matsunaga, Y., Nakatsu, Y., Fukushima, T., Okubo, H., Iwashita, M., Sakoda, H., Fujishiro, M., Yamamotoya, T., Kushiyama, A., Takahashi, S., Tsuchiya, Y., Kamata, H., Tokunaga, F., Iwai, K., and Asano, T.

Mediators Inflamm. 2015:125380, 2015.

Potential biomarkers of fatigue identified by plasma metabolome analysis in rats.

Kume, S., Yamato, M., Tamura, Y., Jin, G., Nakano, M., Miyashige, Y., Eguchi, A., Ogata, Y., Goda, N., Iwai, K., Yamano, E., Watanabe, Y., Soga, T., and Kataoka, Y.

PLoS One 10(3):e0120106, 2015.

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.

MacDuff, D. A., Reese, T. A,, Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., Laplantine, E., Israel, A., Picard, C., Colonna, M., Edelson, B. T., Sibley, L. D., Stallings, C. L., Casanova, J. L., Iwai, K., Virgin, H. W.

eLife 4:e04494, 2015. DOI

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.

Morimoto, D., Walinda, E., Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., Shirakawa, M.

Nature Commun. 6:6116, 2015. DOI

Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC).

Sakamoto, H., Egashira, S., Saito, N., Kirisako, T., Miller, S., Sasaki, Y., Matsumoto, T., Shimonishi, M., Komatsu, T., Terai, T., Ueno, T., Hanaoka, K., Kojima, H., Okabe, T., Wakatsuki, S., Iwai, K., (coreesonding author) and Nagano, T.

ACS Chem Biol. 10:675-681, 2015.

Possible involvement of iron-induced oxidative insults in neurodegeneration.

Asano, T., Koike, M., akata, S.-I., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, H., Uchiyama, Y., Hattori, N., and Iwai, K.

Neurosci. Lett. 588:29-35, 2015.

HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I.

Am. J. Respir, Crit. Care Med. 190(6):688-98, 2014. DOI

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

Rodgers, M.A., Bowman, J.W., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T.J., Iwai, K., Ting, J., Jung, J. U.

J. Exp. Med 211: 1333-1347, 2014. DOI

IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.

Tamiya, H., Terao, M., Takiuchi, T., Nakahara, M., Sasaki, Y., Katayama, I., Yoshikawa, H., and Iwai K.

J. Immunol. 192:3793-3804, 2014.

Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.

Yang, Y., Schmitz, R., Mitala, J. J. Jr., Whiting, A., Xiao, W., Ceribelli, M., Wright, G. W., Zhao, H., Yang, Y., Xu, W., Rosenwald, A., Ott, G., Gascoyne, R. D., Connors, J. M., Rimsza, L. M., Campo, E., Jaffe, E. S., Delabie, J., Smeland, E. B., Braziel, R. M., Tubbs, R. R., Cook, J. R., Weisenburger, D. D., Chan, W. C., Wiestner, A., Kruhlak, M. J., Iwai, K., Bernal, F., and Staudt, L. M.

Cancer Discovery 4:480-493, 2014.

Mechanism underlying IKK activation mediated by the linear ubiquitin chain assembly complex (LUBAC).

Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.

Mol. Cell. Biol. 34:1322-1335, 2014.

Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN.

Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.

Genes Cells. 19:254-272, 2014.

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.

Fujita, N., Morita, E., Itoh, T., Tanaka, A., Nakaoka, M., Osada, Y., Umemoto, T., Saitoh, T., Nakatogawa, H., Kobayashi, S., Haraguchi, T., Guan, J.L., Iwai, K., Tokunaga, F., Saito, K., Ishibashi, K., Akira, S., Fukuda, M., Noda, T., and Yoshimori, T.

J. Cell Biol. 203:115-128, 2013.

Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.

Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, K. and Iwai, K.

EMBO J. 32: 2463- 2476, 2013.

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.

Seki, M., Takeda, Y., Iwai, K., and Tanaka, K.

J. Biol. Chem. 288:16680-16689, 2013.

Two coordinated mechanisms underlie TNFα-induced immediate and delayed IKK activation.

Blackwell, K., Zhang, L., Workman, L.M., Ting, A.T., Iwai, K., Habelhah, H.

Mol. Cell. Biol. 33:1901-1915, 2013.

Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters is an Initial Event in Iron-Dependent Gene Suppression.

Ueta, R., Fujiwara, N., Iwai, K. (Correspondence author) and Yamaguchi-Iwai, Y.

Mol. Cell. Biol. 32:4998-5008, 2012.

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.

Tokunaga, F., Nishimasu, H., Ishitani, R., Goto, E., Noguchi, T., Mio, K., Kamei, K., Ma, A., Iwai, K. and Nureki, O.

EMBO J. 31:3856-3870, 2012.

Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex.

Belgnaoui, S.M., Paz, S., Samuel, S., Goulet, M.L., Sun, Q., Kikkert, M., Iwai, K., Dikic, I., Hiscott, J. and Lin, R.

Cell Host Microbe. 12:211-222, 2012.

Analysis of Nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

Kensche, T., Tokunaga, F., Ikeda, F., Goto, E., Iwai, K. and Dikic, I.

J. Biol. Chem. 287:23626-23634, 2012.

Non-canonical UBA–UBL interaction mediates formation of linear ubiquitin chain assembly complex.

Yagi, H., Ishimoto, K., Takeshi Hiromoto, T., Fujita, H., Mizushima, T., Uekusa, Y., Yagi-Utsumi, M., Kurimoto, E., Noda, M., Uchiyama, S., Tokunaga, F., Iwai, K. (Correspondence author) and Kato, K.

EMBO Rep. 13:462-468, 2012.

Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells.

Tomonaga, M., Hashimoto, N., Tokunaga, F., Onishi, M., Myoui, A., Yoshikawa, H. and Iwai, K.

Int. J. Oncol. 40: 409-417, 2012.

Backbone and side chain (1)H, (13)C, and (15)N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex.

Uekusa, Y., Mimura, S., Sasakawa, H., Kurimoto, E., Sakata, E., Olivier, S., Yagi, H., Tokunaga, F., Iwai, K. and Kato, K.

Biomol. NMR Assign. 6:177-80, 2012.

Specific Recognition of Linear Ubiquitin Chains by the HOIL-1L NZF domain.

Sato, Y., Fujita, H., Yoshikawa, A.,Yamashita, M., Yamagata, A., Kaiser, S. E., Iwai, K., and Fukai, S.

Proc. Natl. Acad. Sci. USA 108:20520-20525, 2011.

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. and Nakayama, K.I.

Cell Metabolism 14: 339–351, 2011.

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO.

Niu, J., Shi, Y., Iwai, K. and Wu, Z.-H.

EMBO J. 30: 3741-3753, 2011.

A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by fenton reaction.

Takatsuka, M., Osada-Oka, M., Satoh, E.F., Kitadokoro, K., Nishiuchi, Y., Niki, M., Inoue, M., Iwai, K., Arakawa, T., Shimoji, Y., Ogura, H., Kobayashi, K., Rambukkana, A. and Matsumoto, S.

PLoS One. 6:e20985, 2011.

Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells.

Asano, T., Komatsu, M., Yamaguchi-Iwai, Y., Ishikawa, F., Mizushima, N. and Iwai, K.

Mol. Cell. Biol. 31:2040-2052, 2011.

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

Ikeda, F., Deribe, Y. L., Skånland, S.S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S.J.L., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, J.P., Rittinger, K., Schaefer, L., Macek, B. and Dikic, I.

Nature 471:637-641, 2011.

SHARPIN is a component of the NF-κB activating linear ubiquitin chain assembly complex.

Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sataka, S.-I., Tanaka, K., Nakano, H., and Iwai, K.

Nature 471:633-636, 2011.

Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction.

Inn, K.-S., Gack, M. U. Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K. (corresponding author) and Jung, J. U.

Molecular Cell 41:354-365, 2011.

Unusual heme binding in the bacterial iron response regulator protein (Irr): Spectral characterization of heme binding to heme regulatory motif.

Ishikawa, H., Nakagaki, M., Bamba, A., Uchida, T., Hori, H., O'Brian, M.R., Iwai, K. and Ishimori K.

Biochemistry 50:1016-1022, 2011.

RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-κB pathway.

Shimada, K., Saeki, M., Egusa, H., Fukuyasu, S., Yura, Y., Iwai, K., and Kamisaki, Y.

Biochem. Biophys. Res. Commun. 404:910-914, 2011.

The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1.

Morikawa, H., Kim, M., Mimuro, H., Punginelli, C., Koyama, T., Nagai, S., Miyawaki, A., Iwai, K. and Sasakawa C.

Biochem. Biophys. Res. Commun. 401:268-274, 2010.

Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.

Kumanomidou, T., Nakagawa, T., Mizushima, T., Suzuki, A., Tokunaga, F., Iwai, K., Yoshida, Y., Tanaka, K. and Yamane, T.

Acta. Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66:95-98 2010.

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation.

Ishii, K., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., and Ikeda, K.

Nature Medicine 15:259-266, 2009.

Involvement of linear polyubiquitination of NEMO in NF-κB activation.

Tokunaga, F., Sakata, S.-I., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K. and Iwai, K.

Nature Cell Biology 11:123-132, 2009.

MDM2 is a novel E3 ligase for HIV-1 Vif.

Izumi, T., Takaori-Kondo, A., Shirakawa, K., Higashitsuji, H., Itoh, K., Io, K., Matsui, M., Iwai, K., Kondoh, H., Sato, T., Tomonaga, M., Ikeda, S., Akari, H., Koyanagi, Y., Fujita, J. and Uchiyama, T.

Retrovirology 6:1, 2009.

Structural basis for specific cleavage of Lys63-linked polyubiquitin chains.

Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai, K., Komada, M. and Fukai, S.

Nature 455:358-362, 2008.

The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase–mediated hypoxia inducible factor-α ubiquitination.

Miyauchi, Y., Kato, M., Tokunaga, F. and Iwai, K.

J. Biol. Chem. 283:16622-16631, 2008.

Gp78 Cooperates with RMA1 in ER-associated Degradation of CFTRΔF508.

Morito, D., Hirao, K., Oda, Y., Hosokawa, N., Tokunaga, F., Cyr, D.M., Tanaka, K., Iwai, K. and Nagata K.

Mol. Biol. Cell 19:1328-1336, 2008.

Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.

Zhou, G., Dada, L.A., Chandel, N.S., Iwai, K., Lecuona, E., Ciechanover, A. and Sznajder, J.I.

FASEB J. 22:1335-1342, 2008.

Fbx8 Makes Arf6 Refractory to Function via Ubiquitination.

Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai, K., Ronai Z, and Sabe H.

Mol. Biol. Cell 19:822-832, 2008.

Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.

Shabek, N., Iwai, K., and Ciechanover, A.

Biochem. Biophys. Res. Commun. 363:425-431, 2007.

Heme induces ubiquitination and degradation of the transcription factor Bach1.

Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K. and Igarashi, K.

Mol. Cell. Biol. 27:6962-6971, 2007.

Cerebral vascular accumulation of Dutch-type Ab42, but not wild-type Ab42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.

Nishitsuji, K., Tomiyama, T., Ishibashi .K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A., Iwai, K. and Mori, H.

J. Neurosci. Res. 85:2917-2923, 2007.

Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.

Ueta, R., Fujiwara, N., Iwai, K. (corresponding author) and Yamaguchi-Iwai, Y.

Mol. Biol. Cell 18:2980-2990, 2007.

A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.

Yoshida, Y., Murakami, A., Iwai, K. and Tanaka, K.

J. Biol. Chem. 282:7137-7144, 2007.

Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity.

Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K. and Kato, K.

Nature Struct. Mol. Biol. 14:167-168, 2007.

Chemoenzymatic Ubiquitination of Artificial Substrates.

Burchak, O.N., Jaquinod, M., Cottin, C., Mugherli, L., Iwai, K., Chatelain, F. and Balakirev. M.Y.

Chembiochem. 7:1667-1669, 2006.

Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC).

Nakamura, M., Tokunaga, F., Sakata , S.-I. and Iwai, K.

Biochem. Biophys. Res. Commun. 351:340-347, 2006.

A ubiquitin ligase complex assembles linear polyubiquitin chains.

Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S. Tokunaga, F., Tanaka, K. and Iwai, K.

EMBO J. 25: 4877–4887, 2006.

The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.

Bayle, J., Lopez, S., Iwai, K., Dubreuil, P. and De Sepulveda, P.

FEBS Lett. 2006 580:2609-2614, 2006.

Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex.

Shirakawa, K., Takaori-Kondo, A., Kobayashi, M., Tomonaga, M., Izumi, T., Fukunaga, K., Sasada, A., Abudu, A., Miyauchi, Y., Akari, H., Iwai, K. and Uchiyama, T.

Virology 344:263-266, 2006.

Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.

Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F. and Iwai, K.

Molecular Cell 19:171-181, 2005.

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex.

Megumi, Y., Miyauchi, Y., Sakurai, H., Nobeyama, H., Lorick, K, Nakamura, E., Chiba, T., Tanaka, K., Weissman, A. M., Kirisako, T., Ogawa, O. and Iwai, K.

Genes Cells 10:679-691, 2005.

Ubiquitination of APOBEC3G by an HIV-1 Vif-cullin5-elonginB-elonginC complex is essential for Vif function.

Kobayashi, M., Takaori-Kondo, A., Miyauchi, Y., Iwai, K. and Uchiyama, T.

J. Biol. Chem. 280:18573-18578. 2005.

Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates.

Yoshida, Y., Adachi, E, Fukiya, K., Iwai, K. and Tanaka K.

EMBO Rep. 6:239-44, 2005.

Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.

Tenno, T., Fujiwara, K., Tochio, H., Iwai, K., Morita, E.H., Hayashi, H., Murata, S., Hiroaki, H., Sato, M., Tanaka, K. and Shirakawa, M.

Genes Cells. 9:865-75, 2004.

Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer.

Nobeyama, H., Sumi, T., Misugi, F., Okamoto, E., Hattori, K., Matsumoto, Y., Yasui, T., Honda, K., Iwai, K. and Ishiko O.

Int. J. Mol. Med. 14:101-105, 2004.

Structural basis of sugar-recognizing ubiquitin ligase.

Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T. and Tanaka, K.

Nature Struct. Mol. Biol. 11: 365-70, 2004.

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron-Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U.V., Land, W., Ollivierre-Wilson, H., Grinberg, A., Love, P. and Rouault, T.A.

EMBO J. 23:386-395, 2004.

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.

Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K. and Tai, T.

J Biol. Chem. 278:43877-43884, 2003.

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.

Ishida, D., Kometani, K., Yang, H., Kakugawa, K., Masuda, K., Iwai, K., Suzuki, M., Itohara, S., Nakahata, T., Hiai, H., Kawamoto, H., Hattori, M. and Minato, N.

Cancer Cell 4:55-65, 2003.

Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

Yamanaka, K., Ishikawa, H., Megumi, Y., Tokunaga, F., Kanie, M., Rouault, T.A., Morishima, I., Minato, N., Ishimori, K. and Iwai, K.

Nature Cell Biology 5:336-340, 2003.

A novel translational control through Iron-Responsive Element by interaction of multifunctional protein YB-1 and IRP2.

Ashizuka, M., Fukuda, T., Nakamura, T., Shirasuna, K., Iwai, K., Izumi, H., Kohno, K., Kuwano M. and Uchiumi, T.

Mol. Cell. Biol. 22:6375-6383, 2002.

E3 ubiquitin-ligase that recognizes sugar chains.

Yoshida, Y., Chiba, T., Tokunaga, F., Kawasaki, H., Iwai, K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K. and Tai, T.

Nature 418: 438-442, 2002.

The NEDD8 pathway is essential for SCFβ-TrCP - mediated ubiquitination and processing of the NF-κB precursor p105.

Amir, R.E., Iwai, K. and Ciechanover, A.

J. Biol. Chem. 277: 23253-23259, 2002.

A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.

Sasaki, A., Masuda. Y., Iwai, K., Ikeda, K. and Watanabe, K.

J. Biol. Chem. 277: 22541-22546, 2002.

The Von Hippel-Lindau (VHL) Tumor Suppressor Protein mediates Ubiquitination of Activated Atypical Protein Kinase C.

Okuda, H., Saitoh, K., Hirai, S.-I., Iwai, K., Takaki, Y., Baba, M., Minato, N., Ohno, S. and Shuin, T.

J. Biol. Chem. 276: 43611-43617, 2001.

NEDD8 recruits E2-ubiquitin to SCF E3 ligase.

Kawakami, T., Chiba, T., Suzuki, T., Yamanaka, K., Iwai, K., Minato, N., Hidaka, Y., Shimbara, N., Suzuki, H., Osaka. F., Omata, M. and Tanaka, K.

EMBO J. 20: 4003-4012, 2001.

Targeted deletion of iron regulatory protein 2 causes iron overload and neurodegenerative disease in mice.

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S.K., Miller, G., Abu-Asab, M., Tsokos, M., Switzer III, R., Grinberg, A., Love, P., Tresser N. and Rouault, T.A.

Nature Genet. 27:209-214, 2001.

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R.C. and Conaway, J.W.

Proc. Natl. Acad. Sci. USA. 97:10430-10435, 2000.

Familial Parkinson's disease gene product, Parkin, is a ubiquitin-protein ligase.

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K. and Suzuki, T.

Nature Genet. 25:302-305, 2000.

SCFβ-TrCP ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase.

Orian, A., Gonen, H., Bercovich, B., Fajerman, I., Eytan, E., Israel, A., Mercurio, F., Iwai, K., Schwartz, A.L. and Ciechanover, A.

EMBO J. 19:2580-2591, 2000.

Differential interaction of plakoglobin andβ-catenin with the ubiquitin-proteasome system.

Sadot, E., Simcha, I., Iwai, K., Ciechanover, A., Geiger, B. and Ben-Ze'ev, A.

Oncogene 19:1992-2001, 2000.

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

Levkowitz, G., Waterman, H., Ettenberg, S. A., Katz, M., Tysgankov, A.Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A., Lipkowitz, S. and Yarden, Y.

Molecular Cell 4:1029-1040, 1999.

Stabilization of iron regulatory protein 2, IRP2, by aluminum.

Yamanaka, K., Minato, N. and Iwai, K.

FEBS Lett. 462:216-220, 1999.

Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex.

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R.C., Conaway, J.W., Klausner, R.D. and Pause, A.

Proc. Natl. Acad. Sci, USA 96:12436-12441, 1999.

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-Induced Conjugation and Subsequent Degradation of IκBα.

Gonen, H., Bercovich, B., Orian, A., Carrano, A. Takizawa, C., Yamanaka, K., Pagano, M., Iwai, K. and Ciechanover, A.

J. Biol. Chem. 274:14823-14830, 1999.

4F2(CD98) Heavy Chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.

Nakamura, E., Sato, M., Yang, H., Miyagawa, F., Harazaki, M., Tomita, K., Matsuoka, H., Noma, A., Iwai, K. and Minato, N.

J. Biol. Chem. 274:3009-3016, 1999.

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins.

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T. M., Minato, N., Klausner, R.D., Levine, R.L. and Rouault, T.A.

Proc. Natl. Acad. Sci. USA 95:4924-4928, 1998.

Human Spa-1 gene product selectively expressed in lymphoid tissues is a specific GTP-ase-activating protein for Rap1 and Rap2: segregate expression profiles from a rap1GAP gene product.

Kurachi, H., Wada, Y., Tsukamoto, N., Maeda, M., Kubota, H., Hattori, M., Iwai, K. and Minato, N.

J. Biol. Chem. 272:28081-28088, 1997.

Mitogen-inducible SIPA1 is mapped to the conserved synthenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human.

Wada, Y., Kubota, H., Maeda, M., Taniwaki, M., Hattori, M., Imamura, S., Iwai, K. and Minato, N.

Genomics 39:66-73, 1997.

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase.

Kim, H.-Y., LaVaute, T., Iwai, K., Klausner, R.D. and Rouault, T.A.

J. Biol. Chem. 271:24226-24230, 1996.

Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.

Butt, J., Kim, H.-Y., Basilion, J. P., Cohen, S., Iwai, K., Philpott, C.C., Altschul, S., Klausner, R.D. and Rouault, T.A.

Proc. Natl. Acad. Sci. USA 93:4345-4349, 1996.

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

Iwai, K., Klausner, R.D. and Rouault, T.A.

EMBO. J. 14:5350-5357, 1995.

Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells.

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J. Biol. Chem. 270:15451-15454, 1995.

Molecular cloning of a novel mitogen-inducible nuclear protein with Ran GTPase activating domain that affects cell cycle progression.

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Mol. Cell. Biol. 15:552-560,1995.

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2: Structure, function and post-translational regulation.

Samaniego, F., Chin, J., Iwai, K., Rouault, T.A. and Klausner, R.D.

J. Biol. Chem. 269:30904-30910, 1994.

Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8-αβ(Vα4/Vβ2) T cells.

Kubota, H., Sato, M., Ogawa, Y., Iwai, K., Hattori, M., Yoshida, T. and Minato, N

Int. Immunol. 6:1323-1331,1994.

Involvement of IL-7 in the development ofγδ T cells in the thymus

Tomana, M., Ideyama, S., Iwai,K., Gyotoku, J.-I., Germeraad, W. T., Muramatsu, S. and Katsura, Y

Thymus 21:141-157, 1993.

In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone.

Murakami, M., Kumagai, S., Sugita, M., Iwai, K. and Imura, H

Clin. Exp. Immunol. 90:245-250,1992.

A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8-αβT cell receptor positive T cells.

Watanabe, Y., Mazda, O., Aiba, Y.-I., Iwai, K., Gyotoku, J.-I., Ideyama, S. and Katsura, Y

Cell. Immunol. 142:385-397,1992.

Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice.

Iwai, K., Tsubata, T., Katsura, Y., Kumagai, S. and Imura, H

Clin. Exp. Immunol. 86:106-111, 1991.

HLA-DQ-specific autoreactive T cell clone with helper and cytotoxic functions.

Sugita, M., Kumagai, S., Umehara, H., Iwai, K., Sorachi, K.-I. and Imura, H

Immunology Letters 26:265-270, 1990.

Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatiod arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells.

Kumagai, S., Ishida, H., Iwai, K., Tsubata, T., Umehara, H., Ozaki, S., Suginoshita, T., Araya, S. and Imura, H

Clin. Exp. Immunol. 78:348-353, 1989.

Heterogeneity in terms of interleukin 4-dependent regulation of Fcε receptor/CD23 expression on chronic B-lymphocytic leukemia cells.

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