Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

Kamura, T., Sato, S., Iwai, K., Czyzyk-Krzeska, M., Conaway, R.C. and Conaway, J.W.

Proc. Natl. Acad. Sci. USA. 97:10430-10435, 2000.

Familial Parkinson's disease gene product, Parkin, is a ubiquitin-protein ligase.

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K. and Suzuki, T.

Nature Genet. 25:302-305, 2000.

SCFβ-TrCP ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase.

Orian, A., Gonen, H., Bercovich, B., Fajerman, I., Eytan, E., Israel, A., Mercurio, F., Iwai, K., Schwartz, A.L. and Ciechanover, A.

EMBO J. 19:2580-2591, 2000.

Differential interaction of plakoglobin andβ-catenin with the ubiquitin-proteasome system.

Sadot, E., Simcha, I., Iwai, K., Ciechanover, A., Geiger, B. and Ben-Ze'ev, A.

Oncogene 19:1992-2001, 2000.

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

Levkowitz, G., Waterman, H., Ettenberg, S. A., Katz, M., Tysgankov, A.Y., Alroy, I., Lavi, S., Iwai, K., Reiss, Y., Ciechanover, A., Lipkowitz, S. and Yarden, Y.

Molecular Cell 4:1029-1040, 1999.

Stabilization of iron regulatory protein 2, IRP2, by aluminum.

Yamanaka, K., Minato, N. and Iwai, K.

FEBS Lett. 462:216-220, 1999.

Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex.

Iwai, K., Yamanaka, K., Kamura, T., Minato, N., Conaway, R.C., Conaway, J.W., Klausner, R.D. and Pause, A.

Proc. Natl. Acad. Sci, USA 96:12436-12441, 1999.

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-Induced Conjugation and Subsequent Degradation of IκBα.

Gonen, H., Bercovich, B., Orian, A., Carrano, A. Takizawa, C., Yamanaka, K., Pagano, M., Iwai, K. and Ciechanover, A.

J. Biol. Chem. 274:14823-14830, 1999.

4F2(CD98) Heavy Chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.

Nakamura, E., Sato, M., Yang, H., Miyagawa, F., Harazaki, M., Tomita, K., Matsuoka, H., Noma, A., Iwai, K. and Minato, N.

J. Biol. Chem. 274:3009-3016, 1999.

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins.

Iwai, K., Drake, S. K., Wehr, N. B., Weissman, A. M., LaVaute, T. M., Minato, N., Klausner, R.D., Levine, R.L. and Rouault, T.A.

Proc. Natl. Acad. Sci. USA 95:4924-4928, 1998.

Human Spa-1 gene product selectively expressed in lymphoid tissues is a specific GTP-ase-activating protein for Rap1 and Rap2: segregate expression profiles from a rap1GAP gene product.

Kurachi, H., Wada, Y., Tsukamoto, N., Maeda, M., Kubota, H., Hattori, M., Iwai, K. and Minato, N.

J. Biol. Chem. 272:28081-28088, 1997.

Mitogen-inducible SIPA1 is mapped to the conserved synthenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human.

Wada, Y., Kubota, H., Maeda, M., Taniwaki, M., Hattori, M., Imamura, S., Iwai, K. and Minato, N.

Genomics 39:66-73, 1997.

Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase.

Kim, H.-Y., LaVaute, T., Iwai, K., Klausner, R.D. and Rouault, T.A.

J. Biol. Chem. 271:24226-24230, 1996.

Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.

Butt, J., Kim, H.-Y., Basilion, J. P., Cohen, S., Iwai, K., Philpott, C.C., Altschul, S., Klausner, R.D. and Rouault, T.A.

Proc. Natl. Acad. Sci. USA 93:4345-4349, 1996.

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

Iwai, K., Klausner, R.D. and Rouault, T.A.

EMBO. J. 14:5350-5357, 1995.

Expression of a constitutive mutant of iron regulatory protein 1 abolishes iron homeostasis in mammalian cells.

DeRusso, P. A., Philpott, C.C., Iwai, K., Mostowski, H.S., Klausner, R.D. and Rouault, T.A.

J. Biol. Chem. 270:15451-15454, 1995.

Molecular cloning of a novel mitogen-inducible nuclear protein with Ran GTPase activating domain that affects cell cycle progression.

Hattori, M., Tsukamoto, N., Nur-E-Kamal, M.S.A., Rubinfeld, B., Iwai, K., Kubota, H., Maruta, H. and Minato, N

Mol. Cell. Biol. 15:552-560,1995.

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2: Structure, function and post-translational regulation.

Samaniego, F., Chin, J., Iwai, K., Rouault, T.A. and Klausner, R.D.

J. Biol. Chem. 269:30904-30910, 1994.

Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8-αβ(Vα4/Vβ2) T cells.

Kubota, H., Sato, M., Ogawa, Y., Iwai, K., Hattori, M., Yoshida, T. and Minato, N

Int. Immunol. 6:1323-1331,1994.

Involvement of IL-7 in the development ofγδ T cells in the thymus

Tomana, M., Ideyama, S., Iwai,K., Gyotoku, J.-I., Germeraad, W. T., Muramatsu, S. and Katsura, Y

Thymus 21:141-157, 1993.

In vitro induction of IgG anti-DNA antibody from high density B cells of systemic lupus erythematosus patients by an HLA DR-restricted T cell clone.

Murakami, M., Kumagai, S., Sugita, M., Iwai, K. and Imura, H

Clin. Exp. Immunol. 90:245-250,1992.

A murine thymic stromal cell line which may support the differentiation of CD4-8- thymocytes into CD4+8-αβT cell receptor positive T cells.

Watanabe, Y., Mazda, O., Aiba, Y.-I., Iwai, K., Gyotoku, J.-I., Ideyama, S. and Katsura, Y

Cell. Immunol. 142:385-397,1992.

Qualitative difference of anti-DNA antibody-producing cell precursors in the pre-immune B cell repertoire between normal and lupus-prone mice.

Iwai, K., Tsubata, T., Katsura, Y., Kumagai, S. and Imura, H

Clin. Exp. Immunol. 86:106-111, 1991.

HLA-DQ-specific autoreactive T cell clone with helper and cytotoxic functions.

Sugita, M., Kumagai, S., Umehara, H., Iwai, K., Sorachi, K.-I. and Imura, H

Immunology Letters 26:265-270, 1990.

Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatiod arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells.

Kumagai, S., Ishida, H., Iwai, K., Tsubata, T., Umehara, H., Ozaki, S., Suginoshita, T., Araya, S. and Imura, H

Clin. Exp. Immunol. 78:348-353, 1989.

Heterogeneity in terms of interleukin 4-dependent regulation of Fcε receptor/CD23 expression on chronic B-lymphocytic leukemia cells.

Ishida, H., Kumagai, S., Iwai, K., Takahashi, T., Kawabe, T., Yodoi, J., N. Arai, N., Namiuchi, S., Konaka, Y. and Imura, H

Nat Commun. 20:323-330, 1989.