Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.
Shabek, N., Iwai, K., and Ciechanover, A.
Biochem. Biophys. Res. Commun.
363:425-431, 2007.
Heme induces ubiquitination and degradation of the transcription factor Bach1.
Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwai, K. and Igarashi, K.
Mol. Cell. Biol.
27:6962-6971, 2007.
Cerebral vascular accumulation of Dutch-type Ab42, but not wild-type Ab42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Nishitsuji, K., Tomiyama, T., Ishibashi .K., Kametani, F., Ozawa, K., Okada, R., Maat-Schieman, M.L., Roos, R.A., Iwai, K. and Mori, H.
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85:2917-2923, 2007.
Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.
Ueta, R., Fujiwara, N., Iwai, K. (corresponding author) and Yamaguchi-Iwai, Y.
Mol. Biol. Cell
18:2980-2990, 2007.
A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.
Yoshida, Y., Murakami, A., Iwai, K. and Tanaka, K.
J. Biol. Chem.
282:7137-7144, 2007.
Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity.
Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K. and Kato, K.
Nature Struct. Mol. Biol.
14:167-168, 2007.