Publications

HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.

MacDuff, D.A., Baldridge, M.T., Qaqish, A.M., Nice, T.J., Darbandi, A.D., Hartley, V.L., Peterson, S.T., Miner, J.J., Iwai, K. and Virgin, H.W

J. Virol. 92(23). pii: e01368-18. doi: 10.1128/JVI.01368-18, 2018. DOI

Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization.

Fujita, H., Tokunaga, A., Shimizu, S., Whiting, A. L., Aguilar-Alonso, F., Takagi, K., Walinda, E., Sasaki, Y., Shimokawa, T., Mizushima, T., Ohki, I., Ariyoshi, M., Tochio, H., Bernal, F., Shirakawa, M., and Iwai, K.

Cell Reports 23(4):1192-1204, 2018. DOI

Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development.

Sasaki, Y. and Iwai, K.

J. Immunol. 200(10):3438-3449, 2018. DOI

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T.H., Iwai, K., Dawson, V.L., Dawson, T.M., and Takahashi, R.

Stem Cell Reports 10(2):356-365, 2018 DOI

Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins.

Ogura, M., Endo, R., Ishikawa, H., Takeda, Y., Uchida, T., Iwai, K., Kobayashi, K., and Ishimori, K

J. Inorg. Biochem 182:238-248. DOI

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

Tamiya, H., Kim, H., Klymenko, O., Kim, H., Feng, Y., Zhang, T., Han, J.Y., Murao, A., Snipas, S.J., Jilaveanu, L., Brown, K., Kluger, H., Zhang, H., Iwai, K., and Ronai, Z.A.

J. Clin. Invest 128(1):517-530, 2018. DOI